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Atorvastatin Calcium ke inhibitor e matla ea HMG-CoA reductase e nang le boleng ba IC50 ba 150 nM[1].
HMG-CoA reductase ke enzyme ea bohlokoa ea tsela ea mevalonate e hlahisang k'holeseterole. HMG-CoA ke enzyme e fokotsang sekhahla 'me e bohlokoa bakeng sa ho theola boemo ba k'holeseterole maling. HMG-CoA reductase e fumaneha ho endoplasmic reticulum mme e na le libaka tse robeli tsa transmembrane. Li-inhibitors tsa HMG-CoA reductase li ka susumetsa maikutlo a li-receptor tsa LDL (low density lipoprotein) sebeteng. E lebisa ho eketsa maemo a "catabolism" a plasma ea LDL le ho theola khatello ea cholesterol ea plasma, e leng sesupo sa bohlokoa sa atherosclerosis. HMG-CoA reductase e bapala karolo ea bohlokoa tlhahisong ea k'holeseterole. HMG-CoA ke sepheo se le seng sa lithethefatsi tse theolang cholesterol. HMG-CoA reductase le eona ke enzyme ea bohlokoa bakeng sa nts'etsopele. Mosebetsi oa HMG-CoA reductase o amana le bofokoli ba ho falla ha likokoana-hloko. Ho thibela tšebetso ea eona ho ka lebisa ho hemorrhage ea intracerebral[1].
Atorvastatin ke HMG-CoA reductase inhibitor e nang le boleng ba IC50 ba 154 nM. E sebetsa hantle ho alafa lefu la dyslipidemia le hypercholesterolemia [1]. Kalafo ea Atorvastatin ka 40 mg e fokotsa k'holeseterole ka 40% kamora matsatsi a 40.[1] E boetse e sebelisoa ho phekola bakuli ba pelo kapa stroke ba nang le maemo a tloaelehileng a k'holeseterole.[2] Atorvastatin e boetse e fokotsa sekhahla sa lipoprotein apheresis ho bakuli ka ho susumetsa maikutlo a li-receptor tsa LDL.
E metabolized ho metabolites tse 'maloa tse bohlokoa bakeng sa phello ea liketso tsa phekolo ka CYP3A4 (cytochrome P450 3A4).[3]
Litšupiso:
[1]. van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Tšebeliso ea nako e telele le polokeho ea atorvastatin kalafo ea mofuta o matla oa III le dyslipidaemia e kopantsoeng. Pelo 2002, 88(3):234-238.
[2]. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al: Thibelo ea liketsahalo tsa coronary le stroke ka atorvastatin ho bakuli ba nang le khatello e phahameng ea mali ba nang le karolelano kapa tlase ho feta. -Karolelano ea likhakanyo tsa k'holeseterole, litekong tsa Anglo-Scandinavia Cardiac Outcomes - Lipid Lowering Arm (ASCOT-LLA): Teko e laoloang ka mefuta e mengata. Lancet 2003, 361(9364):1149-1158.
[3]. Lennernas H: Clinical pharmacokinetics ea atorvastatin. Clin Pharmacokinet 2003, 42(13): 1141-1160.

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