Doxycycline hyclate, eo ka tloaelo e tsejoang e le doxycycline, ke moriana o thibelang likokoana-hloko o sebelisoang hangata ho hlahloba bongaka ba liphoofolo. Ha ho motho ea ka ahlolang feela hore na ke efe e molemo pakeng tsa eona le fluphenazole.
Mmarakeng oa bongaka ba liphoofolo, e 'ngoe ea li-antimicrobial tse tloaelehileng haholo tsa tetracycline ke doxycycline, e leng moriana o tsebahalang haholo ho lihoai le lingaka tsa liphoofolo tsa grassroots. Leha ho le joalo, pharmacology le kopo li hloka boiteko ba litsebi, kahoo u ke ke ua li sebelisa hantle haeba u tloaelane le lithethefatsi tsena feela. Mokhoa oa antibacterial oa doxycycline ke hore haholo-holo o kena ka seleng ea baktheria, o kopanya le sepheo sa subunit sa ribosome 30S, organelle ea sele ea baktheria, kahoo e thibela ho kopana ha liprotheine tsa baktheria, le ho iketsetsa ho bapala phello e sebetsang ea antibacterial.
Ke mafu afe a ka phekoloang ka doxycycline?
Doxycycline e atisa ho sebelisoa bakeng sa phekolo ea mycoplasma ka likhoho le mafu a ho hema likolobe, haholo-holo bakeng sa mafu a tsoakiloeng a mycoplasma le libaktheria.
● Mafu a bakoang ke baktheria
Bakeng sa bakuli ba nang le pleuropneumonia, pneumonia ea likolobe le mafu a mang, ba ka sebelisa doxycycline hydrochloride + fluphenazole + antipyretic lithethefatsi.
Bakeng sa actinomycetes e ka bakang li-pustules tse ka hōlang libakeng tse sa tšoaneng ho kolobe, hangata doxycycline hydrochloride e tla ba le phello e molemo.
● Mafu a tloaelehileng a ’mele
Bakeng sa mycoplasma, e tsejoang hape e le wheezing, doxycycline hydrochloride + flupenthixol e ka sebelisoa.
Spirochetes (letšollo la likolobe, joalo-joalo).
Doxycycline hydrochloride e sebetsa haholo ha e sebelisoa bakeng sa maloetse a kang mali a protozoa, ao hangata re a bitsang epizootics.
Li-antimicrobial tse 'nè tsa mantlha tsa tetracycline
Mmarakeng oa hajoale oa lithethefatsi tsa bongaka ba liphoofolo, li-antimicrobial tse ka sehloohong tsa tetracycline ke doxycycline, tetracycline, oxytetracycline le chlortetracycline, tse nang le phapang e kholo. Haeba o laela ho latela kutloisiso, doxycycline > tetracycline > chlortetracycline > oxytetracycline. Na ua tseba hore na ke hobane'ng ha kutlo ea chlortetracycline e le haufi le oxytetracycline? Ha e le hantle, pele lithibela-mafu li thibeloa lijong, chlortetracycline e ne e sebelisoa lijong tsa liphoofolo haholo, ka tekanyo e tlaase, letsatsi le leng le le leng le nako e telele, feela joalokaha batho ba ja le MSG.
Tekanyo e tlase, e atileng, le ea letsatsi le letsatsi ea phepelo ea chlortetracycline e ntlafalitse ts'ebetso ea liphoofolo mme e khothalelitse nts'etsopele e potlakileng le e phetseng hantle ea indasteri ea temo, eo, leha ho le joalo, e tlisang phello e mpe e kholo, ke hore, lethal dose le joalo, tsela le mekhoa ea ho lema ka bophara. mefuta e mengata ea ho hanyetsa baktheria ho eona. Ka hona, ha mofuta ona oa sethethefatsi o thibetsoe ho sebelisoa phepelong, ke tsoelo-pele e kholo taolong ea tšebeliso ea lithethefatsi tse thibelang likokoana-hloko ho fetola moriana hore e be setlhare se tlamang ho fanoa ka lengolo la ngaka ea liphoofolo. Ho hakanngoa hore, ka mor'a tšebeliso ena e tloaelehileng, ka mor'a nako e telele ea tsosoloso ea tikoloho, kutloisiso ea eona e ka tsosolosoa nakong e tlang.
Hobaneng ha doxycycline e le bohlokoa?
Doxycycline hyclate phofo, e 'ngoe ea lithibela-mafu tse ka sehloohong tsa tetracycline, e' nile ea e-ba e ikhethang tleliniking ea liphoofolo ka lilemo tse ngata hoo e fetohileng mofuta oa bobeli o moholo ka mor'a fluphenazole. Ho phaella moo, tabeng ea phekolo ea mafu a liphoofolo tse ruuoang le likhoho tseo ho leng thata ho li hloekisoa ka nako e khutšoanyane, tse kang ho se feberu, letsoai la air sac, ntaramane, mycoplasma bursa, joalo-joalo, doxycycline e lula e bapala ea eona. karolo e ikhethang ea kalafo kalafong e sebetsang ea bongaka ea mafu ana a mehlape le likhoho. Hangata, kalafong e laetsoeng ke lingaka tsa liphoofolo, ka ho kenya letsoho kapa ntle le ho kenya letsoho ha doxycycline, ka linako tse ling phello ke papali ea zero "e sebetsang hantle" kapa "e sa sebetseng".
Tlhokahalo ea kalafo ea bongaka ea doxycycline indastering ea temo e eketsehile haholo lilemong tse 'maloa tse fetileng ka lebaka la tšenyo ea bursitis, mafu a ho hema a thata ho laola haholo-holo mycoplasma bursa. Haholo-holo mycoplasma bursa, eo hona joale e seng ea nako ea selemo ho hang, e etsahala hangata le hangata ho pholletsa le selemo. Ka hona, ba ela hloko 'maraka oa doxycycline ba tla fumana hore tlhokahalo ea' maraka ea doxycycline e lahlehetsoe ke nako ea eona. Ka lebaka leo, le ha naha e kene ka kakaretso lehlabula le chesang, tlhoko ea 'maraka ea doxycycline ha e so theohe ka lebaka la mocheso o phahameng.
The antimicrobial spectrum eadoxycycline hyclatee lumella ho fumana litlamorao tse ntle tsa kalafo khahlano le libaktheria tsa Gram-positive, Gram-negative, aerobic le anaerobic, hammoho le rickettsia, spirochetes, mycoplasma, chlamydia le protozoa e 'ngoe, e leng lebaka la hore na ke hobane'ng ha doxycycline e amohetsoe ke lihoai le lingaka tsa liphoofolo bakeng sa tse ngata hakana. lilemo. Ho feta moo, matla a phello ea doxycycline ho libaktheria tsa Gram-positive a molemo le ho feta ho libaktheria tsa Gram-negative, haholo-holo ha lithethefatsi tse ngata li sa thuse khahlanong le Staphylococcus, phello ea doxycycline hangata e khotsofatsa.
Ka lebaka leo, har'a li-antimicrobials tse teng tsa tetracycline, doxycycline ha e bapisoe ke likokoana-hloko tse ling tse khahlanong le likokoana-hloko tse tloaelehileng ho mafu a ho hema a kang Staphylococcus, Streptococcus pyogenes le Pneumococcus, e leng e 'ngoe ea mabaka a bohlokoa haholo a hore na ke hobane'ng ha litaelo tse ngata tsa bongaka ba liphoofolo bakeng sa phekolo ea mafu a phefumolohang li ka khona. e fapane haholo le kapa ntle le ho kenya letsoho ha doxycycline.
Menehelo e entsoeng ke CPF
CPF, setsi sa meriana se ka sehloohong lemoetsi oa doxycyclineea li-API le li-formulation tse felileng Chaena li fumana hore ha e le hantle, bafuputsi ba laboratori, ba ka khethang ho hlahloba 'nete ka lefu lena le liphatsa tsa lefutso tsa ho hanyetsa lithethefatsi, ba na le sepheo sa ho qetela sa ho phethela thesis kapa pampiri ea lipatlisiso. Leha ho le joalo, ts'ebetso ena ea lipatlisiso le lipatlisiso, hangata e nka likhoeli kapa lilemo, e leng ho nkang nako e ngata haholo ho etsa lefu le hlokang mokhoa oa ho bula hang-hang bakeng sa ho ema kalafo. Ka hona, kalafo e sebetsang hantle ea tleliniki hangata e ipapisitse le data e fetileng, tlhahlobo ea masimong le tlhahlobo e fokolang e potlakileng ea thuso ea laboratori, ebe joale likhothaletso tsa kalafo e sebetsang li fanoa kapele.
Mofuta ona oa qeto e potlakileng ea lefu le entsoeng ka nako e khuts'oane e tla etsa hore batho ba bangata ba se ke ba utloisisa sethethefatsi, haholo-holo ba ke ke ba khona ho etsa liqeto ka nepo le ka botlalo mabapi le ts'oaetso ea libaktheria tsa pathogenic, sebopeho sa spectrum ho nka lithethefatsi ka bofofu le ho ipapisitse le ho hakanya, eo hape e leng tsela e hlokahalang eo batho ba bangata ba tlamehang ho e nka ka ho khoptjoa le ho thetheha pele ba lula ba hlonepha lingaka tse tummeng le ho fetoha meriana e phethahetseng.
Ka hona, CPF e ikemiselitse ho fapanyetsana le uena tsebo ea tekheniki e amanang le bongaka ba bongaka ba liphoofolo, pharmacology ea bongaka ba liphoofolo, litaelo tsa bongaka ba liphoofolo, maano, taolo, 'maraka le ts'ebeliso, ka sepheo sa ho fihlela ho arolelana tlhahisoleseling, e le hore bahlahlami ba hloelle lere lena ho ea holimo ho ea ithuta. ntho ea bohlokoa.
Nako ea poso: Aug-17-2022