Leano la kalafo bakeng sa myelofibrosis ea mantlha (PMF) le thehiloe holim'a stratification ea kotsi. Ka lebaka la mefuta e fapaneng ea lipontšo le litaba tse lokelang ho rarolloa ho bakuli ba PMF, maano a kalafo a hloka ho ela hloko lefu la mokuli le litlhoko tsa bongaka. Kalafo ea pele ea ruxolitinib (Jakavi / Jakafi) ho bakuli ba nang le spleen e kholo e bontšitse ho fokotseha ho hoholo ha spleen 'me e ne e ikemetse ka boemo ba phetoho ea mokhanni. Bongata bo boholo ba phokotso ea spleen bo fana ka maikutlo a ho fola ho betere. Ho bakuli ba kotsing e tlase ba se nang lefu la bohlokoa la bongaka, ba ka bonoa kapa ba kenngoa litekong tsa bongaka, ka liteko tse pheta-phetoang likhoeli tse ling le tse ling tse 3-6.Ruxolitinib(Jakavi / Jakafi) phekolo ea lithethefatsi e ka qalisoa ho bakuli ba tlaase kapa ba bohareng ba kotsi-1 ba hlahisang splenomegaly le / kapa lefu la kliniki, ho latela tataiso ea phekolo ea NCCN.
Bakeng sa bakuli ba mahareng ba kotsing-2 kapa ba kotsing e kholo, ho khethoa allogeneic HSCT. Haeba transplantation e le sieo, ruxolitinib (Jakavi/Jakafi) e khothaletsoa e le khetho ea pele ea kalafo kapa ho kena litekong tsa bongaka. Ruxolitinib (Jakavi/Jakafi) ke eona feela sethethefatsi se amohetsoeng lefatšeng ka bophara se shebileng tsela e feteletseng ea JAK/STAT, pathogenesis ea MF. Liphuputso tse peli tse hatisitsoeng ho New England Journal le Journal of Leukemia & Lymphoma li fana ka maikutlo a hore ruxolitinib (Jakavi / Jakafi) e ka fokotsa lefu lena haholo le ho ntlafatsa boleng ba bophelo ho bakuli ba PMF. Ho bakuli ba MF ba nang le kotsi e ka hare-2 le ba nang le kotsi e kholo, ruxolitinib (Jakavi / Jakafi) o ile a khona ho fokotsa spleen, ho ntlafatsa maloetse, ho ntlafatsa bophelo, le ho ntlafatsa lefu la masapo, ho finyella lipakane tse ka sehloohong tsa ho laola mafu.
PMF e na le menyetla ea selemo le selemo ea 0.5-1.5 / 100,000 'me e na le tšoaetso e mpe ka ho fetisisa ea li-MPN tsohle. PMF e tšoauoa ka myelofibrosis le extramedullary hematopoiesis. Ho PMF, li-fibroblasts tsa masapo ha li tsoe ho li-clones tse sa tloaelehang. Hoo e ka bang karolo ea boraro ea bakuli ba nang le PMF ha ba na matšoao nakong ea ho hlahlojoa. Litletlebo li kenyelletsa mokhathala o moholo, phokolo ea mali, ho se thabise ka mpeng, letšollo ka lebaka la ho khora kapa splenomegaly, ho tsoa mali, ho theola boima ba 'mele, le ho ruruha ha peripheral edema.Ruxolitinib(Jakavi / Jakafi) e ile ea amoheloa ka August 2012 bakeng sa phekolo ea myelofibrosis e bohareng kapa e phahameng, ho akarelletsa le myelofibrosis e ka sehloohong. Hona joale sethethefatsi se fumaneha linaheng tse fetang 50 lefatšeng ka bophara.