Generic Lebitso:venetoclax (ven ET oh klax)
Lebitso la Brand: Venclexta, Venclexta Starting Pack

Venetoclax e sebelisetsoa ho phekola leukemia e sa foleng ea lymphocytic kapa leukemia e nyenyane ea lymphocytic ho batho ba baholo. Venetoclax e sebelisoa e le mong kapa hammoho le meriana e meng ea mofetše ho phekola maemo ana.

Venetoclax e sebelisoa hammoho le azacitidine, decitabine, kapa cytarabine ho phekola acute myeloid leukemia. Motsoako ona o sebelisoa ho batho ba baholo ba lilemo li 75 kapa ho feta, kapa ba sa khoneng ho sebelisa chemotherapy e tloaelehileng ka lebaka la maemo a mang a bongaka.

Ka linako tse ling Venetoclax e fanoa ka mor'a hore mekhoa e meng ea phekolo e hlōlehe.

Venetoclax e ka boela ea sebelisoa molemong oa merero e sa thathamisitsoeng bukeng ena ea meriana.

Tlhaloso

Venetoclax (ABT-199; GDC-0199) ke inhibitor e matla haholo, e khethang le e fumanehang ka molomo ea Bcl-2 e nang le Ki ea tlase ho 0.01 nM. Venetoclax e baka autophagy.

Ka Vitro

Venetoclax (ABT-199) e bolaea ka matla lisele tsa FL5.12-BCL-2 (EC50 = 4 nM), Venetoclax (ABT-199) e bontša mosebetsi o fokolang haholo khahlanong le lisele tsa FL5.12-BCL-XL (EC50 = 261 nM). ABT-199 e boetse e bonts'a khetho litlhahlobong tsa lisele tsa mammalian tse nyalisitsoeng tse peli, moo e sitisang li-complexes tsa BCL-2-BIM (EC50=3 nM) empa e sa sebetse haholo khahlano le BCL-XL-BCL-XS (EC50=2.2)μM) kapa li-complexes tsa MCL-1-NOXA.

Ka mor'a tekanyo e le 'ngoe ea molomo ea 12.5 mg ka kilo ea boima ba' mele ka xenografts e nkiloeng ho RS4; lisele tsa 11 (ALL), Venetoclax (ABT-199) e baka thibelo e kholo ea ho hōla ha hlahala (TGImax) ea 47% (P <0.001) le kholo ea hlahala. tieho (TGD) ea 26% (P <0.05)[1].

Kalafo ea xenografted e thehiloeng (mohlala oa mouse xenograft ea T-ALL cell line LOUCY) lihlahala tse nang le Venetoclax (ABT-199) 100 mg / kg bakeng sa matsatsi a 4 li fella ka ho fokotseha ho hoholo ha moroalo oa leukemic.