China Daclatasvir Dihydrochloride baetsi le barekisi ba thepa |CPF

Daclatasvir dihydrochloride

Tlhaloso e Khutšoanyane:

Lebitso la API	Pontsho	Tlhaloso	US DMF	EU DMF	CEP
Daclatasvir dihydrochloride	HCV	Ka Ntlong	√

Re romelle lengolo-tsoibila

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Tlhaloso

Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) e matla ebile e sebetsa ka molomo.HCV NS5A protheineinhibitor kaEC₅₀s mefuta e fapaneng ya 9-146 pM bakeng samefuta e mengata ea HCV replicon genotypes.Daclatasvir dihydrochloride le eona ke aanion ea tlhaho e tsamaisang polypeptide 1B (OATP1B)leOATP1B3inhibitor kaIC₅₀s ea 1.5 µM le 3.27 µM, ka ho latellana.

IC₅₀& Sepheo

EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 3 pM) HCV replicon genotype 5a)^[1]
Kd: 8 nM (NS5A33-202) le 210 nM (NS5A26-202)^[2]
IC50: 1.5 µM (OATP1B) le 3.27 µM (OATP1B3)^[3]

Ka Vitro

Daclatasvir (BMS-790052) e bonts'a ts'ebetso e matla ea thibelo ho li-genotype tsohle tse lekiloeng, ka EC.₅₀boleng ho tloha ho 9pm ho isa ho 146 pM.Daclatasvir e thibela HCV replicon genotype 1a, 1b, 2a, 3a, 4a le 5a ka EC₅₀boleng ba 50 pM, 9 pM, 71 pM, 146 pM, 12 pM le 33 pM, ka ho latellana.Daclatasvir ke inhibitor e matla ea kokoana e tšoaetsanoang ea JFH-1 genotype 2a e ikatisang ka setso sa lisele (EC₅₀=28pm)^[1].Daclatasvir (BMS-790052) e tlama ka thata ho NS5A33-202 le NS5A26-202 le K_ds ea 8 nM le 210 nM, ka ho latellana^[2].

Polokelo

Phofo	-20°C	3 lilemo
	4°C	lilemo tse 2
Ka solvent	-80°C	Likhoeli tse 6
	-20°C	1 khoeli

Teko ea Tleliniki

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