Joaloka anticoagulant e ncha ea molomo, rivaroxaban e 'nile ea sebelisoa haholo ho thibela le ho phekola lefu la venous thromboembolic le thibelo ea stroke ho non-valvular atrial fibrillation.E le hore u sebelise rivaroxaban ka mokhoa o utloahalang, u lokela ho tseba bonyane lintlha tsena tse 3.
I. Phapang pakeng tsa rivaroxaban le li-anticoagulants tse ling tsa molomo Hajoale, li-anticoagulants tsa molomo tse sebelisoang hangata li kenyelletsa warfarin, dabigatran, rivaroxaban joalo-joalo.Har'a tsona, dabigatran le rivaroxaban li bitsoa li-anticoagulants tse ncha tsa molomo (NOAC).Warfarin, haholo-holo e na le phello ea eona ea anticoagulant ka ho thibela motsoako oa lintlha tsa coagulation II (prothrombin), VII, IX le X. Warfarin ha e na phello ho lintho tse entsoeng ka coagulation 'me ka hona e na le ts'ebetso e liehang.Dabigatran, haholo-holo ka ho thibela ka ho toba mosebetsi oa thrombin (prothrombin IIa), e na le phello ea anticoagulant.Rivaroxaban, haholo-holo ka ho thibela mosebetsi oa coagulation factor Xa, kahoo ho fokotsa tlhahiso ea thrombin (coagulation factor IIa) ho sebelisa phello ea anticoagulant, ha e ame mosebetsi oa thrombin e seng e hlahisitsoe, ka hona ha e na phello e fokolang mosebetsing oa physiological hemostasis.
2. Matšoao a kliniki ea kotsi ea rivaroxaban vascular endothelial, ho phalla butle ha mali, hypercoagulability ea mali le lintlha tse ling li ka baka thrombosis.Ho bakuli ba bang ba masapo, ho buuoa ka letheka kapa lengole ho atleha haholo, empa ka tšohanyetso ba shoa ha ba tsoha betheng matsatsi a seng makae ka mor'a ho buuoa.Ho ka etsahala hore ebe ke hobane mokuli o ile a ba le thrombosis e tebileng ea methapo ka mor'a ho buuoa 'me a shoa ka lebaka la pulmonary embolism e bakiloeng ke thrombus e ntšitsoeng.Rivaroxaban, e amohetsoe hore e sebelisoe ho bakuli ba baholo ba etsoang opereishene ea letheka kapa lengole ho thibela venous thrombosis (VTE);le bakeng sa phekolo ea deep vein thrombosis (DVT) ho batho ba baholo ho fokotsa kotsi ea ho pheta-pheta DVT le pulmonary embolism (PE) ka mor'a DVT e matla.Atrial fibrillation ke lefu le tloaelehileng la cardiac arrhythmia le ho ata ho fihla ho 10% ho batho ba fetang lilemo tse 75.Bakuli ba nang le atrial fibrillation ba na le tšekamelo ea hore mali a thekesele ka har'a atria le ho etsa maqeba, a ka khelohang le ho lebisa ho stroke.Rivaroxaban, e amohetsoe mme e khothalelitsoe ho bakuli ba baholo ba nang le non-valvular atrial fibrillation ho fokotsa kotsi ea stroke le systemic embolism.Ts'ebetso ea rivaroxaban ha e tlase ho ea warfarin, ketsahalo ea ho tsoa mali ka intracranial e tlase ho feta ea warfarin, 'me ha ho hlokahale hore ho be le ts'ebetso e tloaelehileng ea matla a anticoagulation, joalo-joalo.
3. Tšusumetso ea anticoagulant ea rivaroxaban e ka boleloa esale pele, e nang le fensetere e pharaletseng ea phekolo, ha ho na ho bokella ka mor'a ho noa meriana e mengata, le ho sebelisana ho fokolang le lithethefatsi le lijo, kahoo ho hlahlojoa ha coagulation kamehla ha ho hlokahale.Maemong a ikhethileng, joalo ka ho belaelloang hore ke overdose, liketsahalo tse tebileng tsa mali, opereishene ea tšohanyetso, ho hlaha ha thromboembolic kapa ho belaelloa hore ha ho lateloe melao, ho hlokahala qeto ea nako ea prothrombin (PT) kapa ho hlokahala qeto ea ts'ebetso ea anti-factor Xa.Litlhahiso: Rivaroxaban e sebelisoa haholo ke CYP3A4, e leng substrate ea transporter protein P-glycoprotein (P-gp).Ka hona, rivaroxaban ha ea lokela ho sebelisoa hammoho le itraconazole, voriconazole le posaconazole.