Rivaroxaban phofo

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Rivaroxaban phofo Anticoagulant Ka Ntlong TDP    

Product Qaqileng

Lihlahisoa tsa Product

TLHOKOMELISO PRODUCT

Ka morao

Rivaroxaban phofo, 5-chloro-N - [[((5S) -2-oxo-3- [4- (3-oxomorpholin-4-yl) phenyl] -1,3-oxazolidin-5-yl] methyl] thiophene-2 -carboxamide, ke ntho e matla ea molek'hule e nyane ea molek'hule ea Xa e leng motsoako oa coagulation maemong a mahlonoko tseleng ea mali ea coagulation e hlahisang moloko oa thrombin le sebopeho sa lehloba. Rivaroxaban phofo e tlama ho Tyr288 ka pokothong ea S1 ea factor Xa ka tšebelisano ea Tyr288 le moemeli oa chlorine oa sehlopha sa chlorothiophene. Thibelo e ka khutlisoa (koff = 5x10-3s-1), ka potlako (kon = 1.7x107 mol / L-1 s-1), le ka mokhoa o itšetlehileng ka mahloriso (Ki = 0.4 nmol / L). Hona joale Rivaroxaban phofo e ntse e ithutoa bakeng sa kalafo ea VTE, thibelo ea liketsahalo tsa pelo ho bakuli ba nang le lefu le matla la pelo, thibelo ea setorouku ho bakuli ba nang le mafura a atrial.

Tšupiso

Elisabeth Perzborn, Susanne Roehrig, Alexander Straub, Dagmar Kubitza, Wolfgang Mueck le Volker Laux. Rivaroxaban phofo: ntho e ncha ea molomo Xa inhibitor. Arterioscler Thromb Vasc Biol ea 2010; 30 (3): 376-381

Tlhaloso

Rivaroxaban phofo (BAY 59-7939) e matla haholoFactor Xa (FXa) inhibitor e khethang le e tobileng, ho fihlella leruo le matla ho potency ea anti-FXa (IC50 0.7 nM; Ki 0.4 nM).

 

Ka Vitro

Rivaroxaban powder (BAY 59-7939) ke inhibitor ea molomo, e otlolohileng ea Factor Xa (FXa) nts'etsopele bakeng sa thibelo le kalafo ea thrombosis ea methapo le venous. Rivaroxaban ka tlholisano e thibela motho oa FXa (Ki 0.4 nM) ka> 10 000-fold e kholo ho feta liprotheine tse ling tsa serine; e boetse e thibela tšebetso ea prothrombinase (IC50 2.1 nM). Rivaroxaban phofo e thibela FXa e matla haholo ho plasma ea batho le ea mmutla (IC50 21 nM) ho feta plasma ea rat (IC50 290 nM). E bonts'a litlamorao tsa anticoagulant ka lero la mali la motho, makhetlo a mabeli a prothrombin (PT) mme e kenya nako ea karoloana ea thromboplastin ho 0.23 le 0.69μM, ka ho latellana.

 

Rivaroxaban powder (BAY 59-7939) e matla ebile e khetha, e tobileng FXa inhibitor e nang le ts'ebetso e ntle haholo ea ts'ebetso ea vivo le bioavailability e ntle ea molomo. Rivaroxaban powder (BAY 59-7939), e tsamaisoang ke iv bolus pele thrombus induction, e fokotsa sebopeho sa thrombus (ED50 0.1 mg / kg), e thibela FXa, mme e lelefatsa lethal dose ea PT ka mokhoa o itšetlehileng ka eona. PT le FXa li amehile hanyane ho ED50 (keketseho ea makhetlo a 1.8 le 32 inhibition, ka ho latellana). Ho 0.3 mg / kg (tekanyetso e lebisang ho thibelo e felletseng ea sebopeho sa thrombus), Rivaroxaban phofo e lelefatsa PT (3.2±0.5-fold) mme e thibela ts'ebetso ea FXa (65±3%).

 

Polokelo

Phofo

-20 ° C

Lilemo tse 3
 

4 ° C

lilemo tse 2
Ka solvent

-80 ° C

Likhoeli tse 6
 

-20 ° C

Khoeli e le 'ngoe

Sebopeho sa lik'hemik'hale

Rivaroxaban

NTHATISI

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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