Khalsiamo ea pitavastatin
| 匹伐他汀钙 | Pitavastatin | 147526-32-7 | Ka Ntlong |
| PI-5 | 3800-06-4 | Ka Ntlong | |
| PI-6 | 145516-11-4 | Ka Ntlong | |
| PI-7 | 121660-11-5 | Ka Ntlong |
Tlhaloso
Pitavastatin Calcium (NK-104 hemicalcium) ke matla a matla a hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) e thibela k'holeseterole synthesis ho tloha acetic acid ka IC50 ea 5.8 nM liseleng tsa HepG2. Pitavastatin Calcium ke e sebetsang hantle ea hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Ts'ebetso e khahlanong le mofetše.
Ka morao
Pitavastatin Calcium ke inhibitor ea tlholisano ea enzyme ea HMGCR (HMG-CoA reductase) e fella ka ho fokotseha ha LDL cholesterol synthesis. Liphuputso tse ling li bontša hore pitavastatin e ka hatella tlhahiso ea oksijene liseleng tsa endothelial ka ho thibela NADPH oxidase. Ntle le moo, pitavastatin e fokotsa polelo ea eNOS mRNA ha e ntse e eketsa karabelo e itšetlehileng ka NO e hlohlellelitsoeng ke acetylcholine le calcium ionophore, A23187. Ho feta moo, pitavastatin e thibela ho phahama ha likanale tsa potasiamo tse kentsoeng k'halsiamo ka ho theola boemo ba k'holeseterole liseleng.
Polokelo
4°C, sireletsa leseli
*Ka solvent : -80°C, likhoeli tse 6; -20°C, khoeli e le 'ngoe (sireletsa leseli)
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