Pomalidomide

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TLHOKOMELO SEHLAHISO

Pomalidomide, eo pele e neng e tsejoa e le CC-4047 kapa actimid, ke molek'hule e matla ea immunomodulatory e bonts'ang ts'ebetso ea antineoplastic bakeng sa kalafo ea malignancies ea hematological, haholoholo e khutlelang morao le e hanang ho multiple myeloma (MM). Joaloka motsoako oa thalidomide, pomalidomide e na le sebopeho sa lik'hemik'hale tse tšoanang le tsa thalidomide ntle le ho phaella ha lihlopha tse peli tsa oxo lesale la phthaloyl le sehlopha sa amino sebakeng sa bone. Ka kakaretso, joalo ka molek'hule ea immunomodulatory, pomalidomide e bonts'a ts'ebetso ea antitumor ka mokhoa oa ho thibela tumor microenvironment ka ho feto-fetoha ha li-cytokines tse tšehetsang tumor (TNF-α, IL-6, IL-8 le VEGF), e laolang ka kotloloho mesebetsi ea mantlha ea hlahala. lisele, le ts'ehetso e kopanelang ho tsoa liseleng tse amohelang 'mele tse se nang 'mele.

Pomalidomide e sebelisetsoa ho phekola multipleeloma (kankere e bakoang ke lefu le tsoelang pele la mali). Hangata pomalidomide e fanoa ka mor’a hore bonyane meriana e meng e ’meli e lekoe empa e sa atlehe.

Pomalidomide e boetse e sebelisoa ho phekola Kaposi sarcoma e amanang le AIDS ha meriana e meng e sa sebetse kapa e khaolitse ho sebetsa. pomalidomide e ka boela ea sebelisoa ho phekola Kaposi Sarcoma ho batho ba baholo baHIV-e mpe.

Pomalidomide e fumaneha feela pharmacy e netefalitsoeng tlasa lenaneo le ikhethileng. O tlameha ho ngolisoa lenaneong mme o lumellane le ho sebelisathibelo ea bokhachanemehato kamoo ho hlokahalang.

Pomalidomide e ka boela ea sebelisetsoa merero e sa thathamisitsoeng ho tataiso ea meriana ena.

Pomalidomide e ka baka bokooa bo tebileng, bo behang bophelo kotsing kapa lefu la lesea haeba ’mè kapa ntate a noa pomalidomide nakong ea kemolo kapa nakong ea kemolo. Esita le tekanyo e le ’ngoe ea pomalidomide e ka baka mathata a maholo matsohong le maotong, masapong, litsebeng, mahlo, sefahlehong le pelong ea lesea. Le ka mohla u se ke ua sebelisa pomalidomide haeba u imme. Bolella ngaka ea hau hang-hang haeba nako ea hau e le morao ha u ntse u nka pomalidomide.

TS'ELISO TS'OANELO

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Sehlopha sa Litaba tsa Taolo ea Setsebi se tšehetsa litlhoko tsa boleng nakong ea kopo le ngoliso.

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