China Sacubitril Hemicalcium bahlahisi le ba fanang ka thepa

Sacubitril Hemicalcium

Tlhaloso e Khutšoanyane:

Lebitso la API	Pontsho	Tlhaloso	US DMF	EU DMF	CEP
Sacubitril Hemicalcium		Ka Ntlong

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

TLHOKOMELO SEHLAHISO

沙库比曲半钙盐	Sacubitril Hemicalcium	1369773-39-6	Ka Ntlong
沙库比曲钠盐		149690-05-1	Ka Ntlong
LCZ-4		1426129-50-1	Ka Ntlong
LCZ-7		1012341-48-8	Ka Ntlong
LCZ-8		1012341-50-2	Ka Ntlong
LCZ-9		149690-12-0	Ka Ntlong

Ka morao

AHU-377 hemicalcium letsoai ke mofuta oa letsoai oa hemicalcium oa AHU-377. Ke inhibitor ea neprilysin e nang le boleng ba IC50 ba 5 nM [1].

AHU-377 le mohanyetsi oa angiotensin II AT1 receptor valsartan ba qapa LCZ696 ka karolelano ea 1: 1 molar. LCZ696 ke angiotensin receptor neprilysin inhibitor. E ka fokotsa khatello ea mali 'me e ka ba moriana o mocha oa ho phekola ho hloleha ha pelo. AHU-377 ke pro-drug, e ka fetoloa ka enzymatic cleavage ea ethyl ester ka mokhoa o sebetsang oa LBQ657. Ho tlalehoa hore AHU-377 (30 le 100 mg / kg, PO) e ka baka phello ea antihypertensive ka mokhoa o itšetlehileng ka tekanyo ho likhoto tsa DAHI-SS. Empa ho DOCA-letsoai likhoto tsa khatello ea mali, e bontša ho fokotseha ho fokolang [2, 3].

Litšupiso:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12; 38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Karolo e ka bang teng ea valsartan + AHU377 (LCZ696) ha ho phekoloa lefu la pelo. Setsebi sa Opin Investig Lithethefatsi. 2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Ho bapisa katleho ea AHU-377, neprilysin inhibitor e matla, mefuteng e 'meli ea likhoto tsa khatello ea mali e itšetlehileng ka molumo. BMC Pharmacology 2011, 11(Suppl 1):P33.