Sacubitril Hemicalcium
沙库比曲半钙盐 | Sacubitril Hemicalcium | 1369773-39-6 | Ka Ntlong |
沙库比曲钠盐 | 149690-05-1 | Ka Ntlong | |
LCZ-4 | 1426129-50-1 | Ka Ntlong | |
LCZ-7 | 1012341-48-8 | Ka Ntlong | |
LCZ-8 | 1012341-50-2 | Ka Ntlong | |
LCZ-9 | 149690-12-0 | Ka Ntlong |
Ka morao
AHU-377 hemicalcium letsoai ke mofuta oa letsoai oa hemicalcium oa AHU-377.Ke inhibitor ea neprilysin e nang le boleng ba IC50 ba 5 nM [1].
AHU-377 le mohanyetsi oa angiotensin II AT1 receptor valsartan ba qapa LCZ696 ka karolelano ea 1: 1 molar.LCZ696 ke angiotensin receptor neprilysin inhibitor.E ka fokotsa khatello ea mali 'me e ka ba moriana o mocha oa ho phekola ho hloleha ha pelo.AHU-377 ke pro-drug, e ka fetoloa ka enzymatic cleavage ea ethyl ester ka mokhoa o sebetsang oa LBQ657.Ho tlalehoa hore AHU-377 (30 le 100 mg / kg, PO) e ka baka phello ea antihypertensive ka mokhoa o itšetlehileng ka tekanyo ho likhoto tsa DAHI-SS.Empa ho DOCA-letsoai likhoto tse nang le khatello e matla ea mali, e bontša ho fokotseha ho fokolang [2, 3].
Litšupiso:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.J Med Chem.1995 May 12;38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Karolo e ka bang teng ea valsartan + AHU377 (LCZ696) ha ho phekoloa lefu la pelo.Setsebi sa Opin Investig Lithethefatsi.2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al.Ho bapisa katleho ea AHU-377, neprilysin inhibitor e matla, mefuteng e 'meli ea likhoto tsa khatello ea mali e itšetlehileng ka molumo.BMC Pharmacology 2011, 11(Suppl 1):P33.
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