Sacubitril Hemicalcium

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Ka morao

AHU-377 hemicalcium letsoai ke mofuta oa hemicalcium letsoai la AHU-377. Ke inhibitor ea neprilysin e nang le boleng ba IC50 ba 5 nM [1].

AHU-377 le angiotensin II AT1 receptor antagonist valsartan ba ngola LCZ696 ka 1: 1 molar ratio. LCZ696 ke angiotensin receptor neprilysin inhibitor. E ka fokotsa khatello ea mali mme e kanna ea ba sethethefatsi se ncha sa kalafo ea ho hloleha ha pelo AHU-377 ke pro-drug, e ka fetoloa ke phepelo ea enzymatic ea ethyl ester hore e be foromo e sebetsang ea LBQ657. Ho tlalehoa hore AHU-377 (30 le 100 mg / kg, PO) e ka baka tšusumetso e matla ea khatello ea mali ka mokhoa o itšetlehileng ka tekanyetso ho likhoto tsa DAHI-SS. Empa ho likhoto tse nang le khatello ea mali e ngata ea DOCA, e bonts'a phokotso e fokolang [2, 3].

Litšupiso:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide e sa nke lehlakore endopeptidase inhibitors. J Med Chem. 1995 Mots'eanong la 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Karolo e ka bang teng ea valsartan + AHU377 (LCZ696) kalafong ea ho hloleha ha pelo. Setsebi Opin Investig Lithethefatsi. 2013 Aug; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Ts'ebetso e sebetsang ea papiso ea AHU-377, e matla ea neprilysin inhibitor, mefuteng e 'meli ea likhoto ea khatello e phahameng ea khatello ea mali. BMC Pharmacology 2011, 11 (Tlatsetso ea 1): P33.

Sebopeho sa lik'hemik'hale

Sacubitril Hemicalcium

NTHATISI

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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