Agomelatine
Ka morao
Agomelatine ke agonist ea melatonin receptors le mohanyetsi oa serotonin 5-HT2C receptor ka Ki values ea 0.062nM le 0.268nM le IC50 boleng ba 0.27μM, ka ho latellana bakeng sa MT1, MT2 le 5-HT2C [1].
Agomelatine ke sethethefatsi se ikhethileng se thibelang ho imeloa kelellong 'me se etselitsoe ho phekola lefu le leholo la khatello ea maikutlo (MDD). Agomelatine e khetha khahlano le 5-HT2C. E bonts'a likamano tse tlase ho batho ba 5-HT2A le 5-HT1A. Bakeng sa li-receptor tsa melatonin, agomelatine e bonts'a likamano tse ts'oanang le MT1 ea motho le MT2 e nang le boleng ba Ki ea 0.09nM le 0.263nM, ka ho latellana. Lithutong tsa in vivo, agomelatine e baka keketseho ea maemo a dopamine le noradrenaline ka ho thibela tlhahiso ea inhibitory ea 5-HT2C. Ho feta moo, tsamaiso ea agomelatine e loantša ho fokotseha ho bakoang ke khatello ea kelello ho sebelisoa ha sucrose ka mokhoa oa likhoto oa khatello ea maikutlo. Ntle le moo, agomelatine e na le katleho e fokotsehileng ea ho tšoenyeha ka mohlala oa litoeba tsa matšoenyeho [1].
Litšupiso:
[1] Zupancic M, Guilleminault C. Agomelatine. Lithethefatsi tsa CNS, 2006, 20 (12): 981-992.
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