Agomelatine
Ka morao
Agomelatine ke agonist ea melatonin receptors le mohanyetsi oa serotonin 5-HT2C receptor ka Ki values ea 0.062nM le 0.268nM le IC50 boleng ba 0.27μM, ka ho latellana bakeng sa MT1, MT2 le 5-HT2C [1].
Agomelatine ke sethethefatsi se ikhethileng se thibelang ho imeloa kelellong 'me se etselitsoe ho phekola lefu la khatello ea maikutlo le leholo (MDD).Agomelatine e khetha khahlano le 5-HT2C.E bonts'a likamano tse tlase ho batho ba 5-HT2A le 5-HT1A.Bakeng sa li-receptor tsa melatonin, agomelatine e bonts'a likamano tse ts'oanang le MT1 ea motho le MT2 e nang le boleng ba Ki ea 0.09nM le 0.263nM, ka ho latellana.Lithutong tsa in vivo, agomelatine e baka keketseho ea maemo a dopamine le noradrenaline ka ho thibela tlhahiso ea inhibitory ea 5-HT2C.Ho feta moo, tsamaiso ea agomelatine e hanana le ho fokotseha ho bakoang ke khatello ea kelello ho sebelisoa ha sucrose ka mokhoa oa likhoto oa khatello ea maikutlo.Ntle le moo, agomelatine e na le ts'ebetso e fokotsehileng ea ho tšoenyeha ka mokhoa oa ho tšoenyeha [1].
Litšupiso:
[1] Zupancic M, Guilleminault C. Agomelatine.Lithethefatsi tsa CNS, 2006, 20 (12): 981-992.
Sebopeho sa lik'hemik'hale
Tlhahiso18Merero ea Tlhahlobo ea Boleng e amohetsoeng4, le6merero e tlas'a tumello.
Sistimi e tsoetseng pele ea boleng ba machaba e thehile motheo o tiileng oa thekiso.
Tlhokomelo ea boleng e tsamaisana le potoloho eohle ea bophelo ba sehlahisoa ho netefatsa boleng le phello ea kalafo.
Sehlopha sa Litaba tsa Taolo ea Setsebi se tšehetsa litlhoko tsa boleng nakong ea kopo le ngoliso.
Korea Countec Bottled Packaging Line
Taiwan CVC Bottled Packaging Line
Italy CAM Board Packaging Line
Mochini oa Sejeremane oa Fette Compacting
Japan Viswill Tablet Detector
Kamore ea ho laola ea DCS
