China Bictegravir 1611493-60-7 baetsi le bafani ba thepa |CPF

Bictegravir 1611493-60-7

Tlhaloso e Khutšoanyane:

Lebitso la API	Pontsho	Moqapi	Letsatsi la Phello ea Patent(US)
Bictegravir 1611493-60-7	tšoaetso ea HIV-1	Saense ea Gileade	La 19 Tšitoe 2033

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

TLHAKISO SEHLAHISO

Tlhaloso

Bictegravir ke novele, inhibitor e matla ea HIV-1 integrase e nang le IC50 ea 7.5 nM.

Ka Vitro

Bictegravir (BIC) e thibela tšebetso ea phetiso ea likhoele ka IC50 ea 7.5± 0.3 nM.Mabapi le ho thibela ts'ebetso ea phetisetso ea strand, Bictegravir ke inhibitor e fokolang haholo ea 3."- ts'ebetso ea ts'ebetso ea HIV-1 IN, e nang le IC50 ea 241±51 nM.Bictegravir e ntlafatsa ho bokellana ha li-circles tsa 2-LTR ~ 5-fold tse amanang le taolo e songoang le ho fokotsa palo ea lihlahisoa tsa 'nete tsa ho kopanya liseleng tse nang le tšoaetso ka makhetlo a 100.Bictegravir e thibela ho ikatisa ha HIV-1 ka bobeli liseleng tsa MT-2 le MT-4 tse nang le EC50s tsa 1.5 le 2.4 nM, ka ho latellana.Bictegravir e bonts'a litlamorao tse matla tsa antiviral ho li-lymphocyte tsa mantlha tsa CD4+ T le li-macrophages tse tsoang monocyte, tse nang le EC50s ea 1.5±0.3 nM le 6.6±4.1 nM, ka ho latellana, e ka bapisoang le litekanyetso tse fumanoang meleng ea T-cell[1].

MCE ha e e-so tiise ka boikemelo ho nepahala ha mekhoa ena.Ke tsa litšupiso feela.

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