Captopril
Tlhaloso
Captopril (SQ-14534) ke inhibitor e matla, e nang le tlhōlisano ea angiotensin-converting enzyme (ACE).
Ka Vitro
Captopril (SQ-14534) e bontšitsoe hore e na le melemo e tšoanang ea ho kula le ho shoa ho feta ea diuretics le beta-blockers ho bakuli ba nang le khatello e phahameng ea mali.Captopril (SQ-14534) e bonts'itse hore e liehisa tsoelo-pele ea lefu la tsoekere, 'me enalapril le lisinopril li thibela nts'etsopele ea nephropathy ho bakuli ba normoalbuminuric ba nang le lefu la tsoekere [1].Karo-karolelano e lekanang ea li-cis le li-trans States tsa Captopril (SQ-14534) e teng ka tharollo le hore enzyme e khetha feela trans state ea inhibitor e hlahisang meralo le stereoelectronic complementarity le substrate e tlamang groove[2].
MCE ha e e-so tiise ka boikemelo ho nepahala ha mekhoa ena.Ke tsa litšupiso feela.
Teko ea Tleliniki
| Nomoro ea NCT | Motšehetsi | Boemo | Letsatsi la qalo | Mokhahlelo |
| NCT03179163 | Penn State University|Setsi sa Naha sa Pelo, Matšoafo le Mali (NHLBI) | Hypertension, ea bohlokoa | La 20 Phupu 2016 | Mokhahlelo oa 1|Mokhahlelo oa 2 |
| NCT03660293 | Univesithi ea Tanta | Lefu la tsoekere mellitus, Mofuta oa 1 | La 1 Mmesa 2017 | Ha e sebetse |
| NCT03147092 | Centro Neurológico de Pesquisa e Reabiitação, Brazil | Khatello ea mali | Khatello ea Mali | Hlakola 1, 2018 | Mohato oa pele oa 1 |
| NCT00252317 | Rigshospitalet, Denmark | Aortic stenosis | November 2005 | Mokhahlelo oa 4 |
| NCT02217852 | Sepetlele sa West China | Khatello ea mali | Phato 2014 | Mokhahlelo oa 4 |
| NCT01626469 | Brigham le Sepetlele sa Basali | Mofuta oa 2 oa lefu la tsoekere mellitus | Motšeanong 2012 | Mokhahlelo oa 1|Mokhahlelo oa 2 |
| NCT00391846 | AstraZeneca | Ho hloleha ha Pelo|Ho se sebetse hantle ha Ventricular, ka ho le letšehali | Mphalane 2006 | Mokhahlelo oa 4 |
| NCT00240656 | Univesithi ea Bongaka ea Hebei | Khatello ea mali, Pulmonary | Mphalane 2005 | Mokhahlelo oa 1 |
| NCT00086723 | Univesithi ea Northwestern | Setsi sa Naha sa Kankere (NCI) | Hlahala e Tiileng e sa Boleloeng ea Batho ba Baholo, e Ikhethileng | Phupu 2003 | Mokhahlelo oa 1|Mokhahlelo oa 2 |
| NCT00663949 | Shiraz University of Medical Sciences | Nephropathy ea lefu la tsoekere | Hlakola 2006 | Mokhahlelo oa 2|Mokhahlelo oa 3 |
| NCT01437371 | Sepetlele sa Univesithi, Clermont-Ferrand|Servier|LivaNova | Ho hloleha ha Pelo | Phato 2011 | Mokhahlelo oa 3 |
| NCT04288700 | Univesithi ea Ain Shams | Infantile Hemangioma | La 1 Mphalane 2019 | Mokhahlelo oa 4 |
| NCT00223717 | Univesithi ea Vanderbilt | Setsi sa Bongaka sa Univesithi ea Vanderbilt | Khatello ea mali | Pherekhong 2001 | Mokhahlelo oa 1 |
| NCT02770378 | Univesithi ea Ulm| Litlhare tse Tšepahalang tsa Kankere| Letlole la Anticancer, Belgium | Glioblastoma | Pulungoana 2016 | Mokhahlelo oa 1|Mokhahlelo oa 2 |
| NCT01761916 | Instituto Materno Infantil Prof. Fernando Figueira | Preeclampsia | Pherekhong 2013 | Mokhahlelo oa 4 |
| NCT01545479 | Instituto de Cardiologia ho ea Rio Grande do Sul | Lefu la Renal | Pherekhong 2010 | Mokhahlelo oa 4 |
| NCT00935805 | Hospital de Clinicas de Porto Alegre|Conselho Nacional de Desenvolvimento Científico e Tecnológico|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil | Lefu la tsoekere mellitus | Arterial Hypertension | Phupu 2006 |
|
| NCT00742040 | Sepetlele sa Bana ba kulang | Lefu la Pelo | Phato 2008 | Mokhahlelo oa 2 |
| NCT03613506 | Univesithi ea Wuhan | Radiotherapy Side Effect| Ho nka Captopril | La 25 Mphalane, 2018 | Mokhahlelo oa 2 |
| NCT00004230 | Univesithi ea Northwestern | Setsi sa Naha sa Kankere (NCI) | Kankere | Mphalane 1999 | Mokhahlelo oa 3 |
| NCT00660309 | Novartis | Mofuta oa 2 oa lefu la tsoekere mellitus | Mmesa 2008 | Mokhahlelo oa 4 |
| NCT00292162 | NHS Greater Glasgow le Clyde | Ho hloleha ho sa Feleng ha Pelo | Atrial Fibrillation | Pherekhong 2007 | Ha e sebetse |
| NCT01271478 | Coordinación de Investigación en Salud, Mexico | Ho ruruha|Boloetse ba Renal bo qetellang | Phato 2009 | Mokhahlelo oa 4 |
| NCT04193137 | Univesithi ea Bongaka ea Chongqing | Aldosteronism ea mantlha | La 30 Pulungoana 2019 |
|
| NCT00155064 | Sepetlele sa Naha sa Univesithi ea Taiwan | Hyperaldosteronism | Phupu 2002 | Mokhahlelo oa 4 |
| NCT01292694 | Univesithi ea Vanderbilt | Setsi sa Bongaka sa Univesithi ea Vanderbilt | Khatello ea mali | Ho hloleha ho Ikemetseng ho Hloekileng | Atrophy ea Sisteme e Mengata | Hlakubele 2011 | Mokhahlelo oa 1 |
| NCT00917345 | Sepetlele sa Naha sa Univesithi ea Taiwan | Novartis | Aldosteronism ea mantlha | Pherekhong 2008 |
|
| NCT00077064 | Sehlopha sa Therapy Therapy Oncology|Setsi sa Naha sa Kankere (NCI)|NRG Oncology | Kankere ea Matšoafo | Mathata a Pulmonary | Radiation Fibrosis | Phuptjane 2003 | Mokhahlelo oa 2 |
Polokelo
| Phofo | -20°C | 3 lilemo |
| 4°C | lilemo tse 2 | |
| Ka solvent | -80°C | Likhoeli tse 6 |
| -20°C | 1 khoeli |
Sebopeho sa lik'hemik'hale
Tlhahiso18Merero ea Tlhahlobo ea Boleng e amohetsoeng4, le6merero e tlas'a tumello.
Sistimi e tsoetseng pele ea boleng ba machaba e thehile motheo o tiileng oa thekiso.
Tlhokomelo ea boleng e tsamaisana le potoloho eohle ea bophelo ba sehlahisoa ho netefatsa boleng le phello ea kalafo.
Sehlopha sa Litaba tsa Taolo ea Setsebi se tšehetsa litlhoko tsa boleng nakong ea kopo le ngoliso.
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