Ka morao

Canagliflozin ke buka e ncha, e matla ebile e khetha haholo sodium glucose co-transporter (SGLT) 2 inhibitor [1].Ho 'nile ha pakoa hore Canagliflozin e ka eketsa ho ntšoa ha tsoekere ea moroto ka ho fokotsa sekhahla sa tsoekere ea renal le ho fokotsa ho monya hape ha tsoekere e tlhotliloeng.

Canagliflozin e bontšitsoe hore e thibela ho kenngoa ha Na+-mediated 14C-AMG ho CHO-hSGLT2, CHO-rat SGLT2 le CHO-mouse SGLT2 e nang le IC50 boleng ba 4.4, 3.7 le 2.0 nM, ka ho latellana [1].

Ho tlalehiloe hore Canagliflozin e fokotsa maemo a tsoekere ea mali (BG) ho latela litoeba tsa db/db le Zucker diabetic fatty (ZDF) Rats.Ho feta moo, canagliflozin e ipakile e fokotsa sekhahla sa phapanyetsano ea phefumoloho, le boima ba 'mele ho litoeba tsa DIO le likhoto tsa ZDF [1].

Canagliflozin e ka nooa ka molomo.

Litšupiso:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Phello ea canagliflozin monyako oa renal bakeng sa tsoekere, glycemia, le boima ba 'mele mefuteng e tloaelehileng ea liphoofolo tsa lefu la tsoekere.PLoS One.2012;7(2):e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), Novel Molomo Agent For Type-2 Diabetes.P T. 2013 Nov;38(11):656-66

Tlhahiso ea Sehlahisoa

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al."Mekhoa e fapaneng ea tharollo bakeng sa taolo ea li-spectra tse fetelletseng: Kopo ea ho tsebahatsa litlhare tse ncha tse kopantsoeng tsa hypoglycemic ka foromo ea bona ea litekanyetso tse kopaneng tsa meriana."Spectrochimica Acta Karolo ea A: Molek'hule le Biomolecular Spectroscopy E fumaneha Inthaneteng 20 June 2018.

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