Tlhaloso

Rosuvastatin Calcium (BANM, JAN, USAN) e tsejoa e le Rosuvastatin naheng ea Amerika. le HMG-CoA reductase inhibitor ea tlholisano e nang le IC50 ea 11 nM[1]. Rosuvastatin Calcium e thibela ka matla gene e amanang le ether-a-go-go (hERG) ea hona joale e nang le IC50 ea 195 nM, e liehile ho repolarization ea pelo, 'me ka hona e nka nako e telele e ka bang teng (APDs) le ho lokisa linako tsa QT (QTc) [2]. Rosuvastatin Calcium e fokotsa polelo ea hERG e butsoitseng le tšebelisano ea protheine ea mocheso oa 70 (Hsp70) le protheine ea hERG. Rosuvastatin Calcium e sebetsa hantle haholo ho theoleng k'holeseterole e tlaase-tlaase-density lipoprotein (LDL), triglycerides, le liprotheine tsa C-reactive [3].

Tlhahisoleseding e eketsehileng mabapi le ditumellano tsa ho reha dithethefatsi: Mabitso a Matjhaba a sa rerelweng.

Tsebiso ea Bohlokoa: Lebenkele la machaba la Drugs.com le lokollotsoe ka BETA. Sena se bolela hore e ntse e ntlafatsoa 'me e kanna ea ba le liphoso. Ha e reretsoe ho nka sebaka sa botsebi le kahlolo ea ngaka ea hau, rakhemisi kapa setsebi se seng sa tlhokomelo ea bophelo. Ha ea lokela ho hlalosoa ho bontša hore tšebeliso ea meriana leha e le efe naheng leha e le efe e bolokehile, e loketse kapa e sebetsa ho uena. Ikopanye le setsebi sa tlhokomelo ea bophelo pele u noa meriana leha e le efe.

Naheng ea Amerika, Rosuvastatin (rosuvastatin systemic) ke setho sa sehlopha sa lithethefatsi tsa statins mme e sebelisoa ho phekola Atherosclerosis, Cholesterol e Phahameng, Cholesterol e Phahameng - Familial Heterozygous, High Cholesterol - Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa - Elevated LDL, Hyperlipopro IIb - e phahameng LDL VLDL, Hyperlipoproteinemia Mofuta oa III - E phahameng ea beta-VLDL IDL, Hyperlipoproteinemia Mofuta oa IV - VLDL e phahameng, Hypertriglyceridemia le Thibelo ea Mafu a pelo.

Ka morao

Inhibitor e khethang, e nang le tlholisano ea HMG-CoA reductase, eo hape e leng antilipemic.

Polokelo

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