Tlhaloso

Sugammadex sodium ke motsoako oa maiketsetso oa γ-cyclodextrin, 'me o sebetsa e le ntho e ncha e fetolang bakeng sa "neuromuscular block".

Lebitso la tlhaho: sugammadex (soo GAM ma dex)
Lebitso la Brand: Bridion

Sugammadex e fetola liphello tsa meriana e itseng e fanoang nakong ea ho buuoa ho phomola mesifa ea hau.

Sugammadex e sebelisoa qetellong ea ho buuoa, ho thusa ho tsosolosa mosebetsi oa mesifa o thibetsoeng nakong ea ho buuoa ke meriana e meng.

Sugammadex e ka boela ea sebelisoa molemong oa merero e sa thathamisitsoeng ho tataiso ena ea meriana.

E sebelisoa ho khutlisa litlamorao tsa lithethefatsi tse ling.

Ho Vivo

Ente ea sugammadex ha e na litlamorao tse kholo khatellong ea mali kapa lebelo la pelo.Ka mor'a ente ea tekanyo e phahameng ea rocuronium, ho tsosolosoa ha 90% ea tekanyo ea terene ea tse 'nè ho nka 28 min (SD 7 min) ka mor'a saline, 26 min (SD 9.5 min) ka mor'a 1 mg / kg sugammadex, le 8 min (SD) 3.6 min) ka mor'a 2.5 mg / kg sugammadex [1].Sugammadex e baka phetoho e potlakileng le e felletseng ea "rocuronium-induced neuromuscular block".Nako ea ho hlaphoheloa ea ho koetlisa karo-karolelano e mene = 0.9 ka mor'a ho hlaphoheloa ka tšohanyetso ke 14.4 min (SD = 3.4 min; n = 14).Sena se fokotsehile haholo ho 3.7 min (SD = 3.3 min; n = 4) le sugammadex 0.5 mg / kg le ho 1.9 min (SD = 1.0 min; n = 4) le sugammadex 1.0 mg / kg [2].Halofo ea bophelo ba sugammadex ho Rhesus monkey ke 30 (SEM = 4.9) min[3].

Polokelo

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