Vericiguat

Tlhaloso e Khutšoanyane:

Lebitso la API Pontsho Moqapi Letsatsi la Phello ea Patent(US)
Vericiguat Ho hloleha ha pelo Bayer le MSD Mots'eanong.La 24, 2031


Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

TLHAKISO SEHLAHISO

Vericiguat kepyrazolopyridineke hore5-fluoro-1H-pyrazolo[3,4-b]pyridinemoo amino hydrogen e boemong ba 1 e nketsoeng sebaka ke sehlopha sa 2-fluorobenzyl lehaedrojenesebakeng sa 3 se nkeloe sebaka ke sehlopha sa 4,6-diamino-5--[(methoxycarbonyl) amino]pyrimidin-2-yl.Ke ntho e qhibilihangguanylatecyclase stimulator e sebelisetsoang ho phekola lefu la pelo le sa foleng.E na le karolo ea ho qhibilihaguanylatecyclase activator, moemeli oa vasodilator le moemeli oa antihypertensive.Keaminopyrimidine,apyrazolopyridine, carbamate ester le motsoako oa organofluorine.

Vericiguat e ntse e etsoa lipatlisiso tekong ea bongaka ea NCT02861534 (Phuputso ea Vericiguat ho Barupeluoa ba Nang le Ho Hloka Pelo ka Karolo e Fokotseng ea Ejection (HFrEF) (MK-1242-001)).

Vericiguat ke SolubleGuanylateCyclase Stimulator.Mokhoa oa ts'ebetso oa vericiguat ke joalo kaGuanylateCyclase Stimulator.

Vericiguat ke meriana e sebelisoang ho laola le ho phekola ho hloleha ha pelo ka karolo e fokotsehileng ea ejection (HFrEF).E na le thuso bakeng sa ho nyekeloa ke pelo ho sa foleng, ho hloleha ha pelo ha morao tjena.Vericiguat ha e lelefatse ho phela empa e thibela ho khutlisetsoa sepetlele.Ketsahalo ena e hlalosa matšoao, mokhoa oa ts'ebetso, lethal dose, le mokhoa oa tsamaiso ke sehlopha sa litsebi, liphello tse mpe, li-contraindications, le liteko tse 'maloa ho tšehetsa bopaki ba molemo oa lithethefatsi ho HFrEF.

TSAMAISO KHABANE

Quality management1

Tlhahiso18Merero ea Tlhahlobo ea Boleng e amohetsoeng4, le6merero e tlas'a tumello.

Quality management2

Sistimi e tsoetseng pele ea boleng ba machaba e thehile motheo o tiileng oa thekiso.

Quality management3

Tlhokomelo ea boleng e tsamaisana le potoloho eohle ea bophelo ba sehlahisoa ho netefatsa boleng le phello ea kalafo.

Quality management4

Sehlopha sa Litaba tsa Taolo ea Setsebi se tšehetsa litlhoko tsa boleng nakong ea kopo le ngoliso.

TS'ELISO TS'OANELO

cpf5
cpf6

Korea Countec Bottled Packaging Line

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Taiwan CVC Bottled Packaging Line

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Italy CAM Board Packaging Line

cpf11

Mochini oa Sejeremane oa Fette Compacting

cpf12

Japan Viswill Tablet Detector

cpf14-1

Kamore ea ho laola ea DCS

MOTHOANA

Tšebelisano ea machaba
International cooperation
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Domestic cooperation

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